| Players | Clubs | Position | Total | Goals | A |  |
 |
 |
Start | Sub | CO | Off | Pen S | Pen SV | Pen M | Pen C | OG | More |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lukas Hradecky | Bayer Leverkusen | Goalkeeper | 34 | 0 | 0 | 1 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | |
| Sven Bender | Bayer Leverkusen | Midfielder | 33 | 2 | 1 | 3 | 0 | 0 | 33 | 1 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | |
| Kai Havertz | Bayer Leverkusen | Midfielder | 30 | 12 | 6 | 3 | 0 | 0 | 29 | 2 | 1 | 9 | 1 | 0 | 0 | 0 | 0 | |
| Nadiem Amiri | Bayer Leverkusen | Midfielder | 30 | 1 | 2 | 3 | 0 | 0 | 22 | 12 | 8 | 11 | 0 | 0 | 0 | 0 | 0 | |
| Moussa Diaby | Bayer Leverkusen | Midfielder | 28 | 5 | 5 | 3 | 0 | 0 | 18 | 16 | 10 | 6 | 0 | 0 | 0 | 0 | 0 | |
| Kevin Volland | Bayer Leverkusen | Forward | 27 | 10 | 7 | 3 | 0 | 0 | 24 | 4 | 3 | 7 | 0 | 0 | 0 | 0 | 0 | |
| Charles Aranguiz | Bayer Leverkusen | Midfielder | 27 | 1 | 3 | 2 | 0 | 0 | 23 | 4 | 4 | 9 | 0 | 0 | 0 | 0 | 0 | |
| Julian Baumgartlinger | Bayer Leverkusen | Midfielder | 27 | 2 | 2 | 4 | 0 | 0 | 20 | 9 | 7 | 7 | 0 | 0 | 0 | 0 | 0 | |
| Karim Bellarabi | Bayer Leverkusen | Midfielder | 26 | 4 | 6 | 2 | 0 | 0 | 17 | 11 | 9 | 11 | 0 | 0 | 0 | 0 | 0 | |
| Jonathan Tah | Bayer Leverkusen | Defender | 25 | 0 | 1 | 4 | 0 | 1 | 22 | 9 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Kerem Demirbay | Bayer Leverkusen | Midfielder | 25 | 1 | 5 | 3 | 1 | 0 | 18 | 14 | 7 | 9 | 0 | 0 | 0 | 0 | 0 | |
| Wendell | Bayer Leverkusen | Defender | 24 | 0 | 2 | 5 | 1 | 0 | 21 | 8 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | |
| Lucas Alario | Bayer Leverkusen | Forward | 24 | 7 | 1 | 6 | 0 | 0 | 11 | 22 | 13 | 4 | 1 | 0 | 0 | 0 | 0 | |
| Leon Bailey | Bayer Leverkusen | Midfielder | 22 | 5 | 3 | 0 | 0 | 2 | 12 | 11 | 10 | 11 | 0 | 0 | 0 | 0 | 0 | |
| Lars Bender | Bayer Leverkusen | Midfielder | 18 | 2 | 1 | 3 | 0 | 0 | 16 | 4 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | |
| Mitchell Weiser | Bayer Leverkusen | Midfielder | 18 | 1 | 0 | 3 | 0 | 0 | 14 | 12 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | |
| Aleksander Dragovic | Bayer Leverkusen | Defender | 15 | 0 | 0 | 6 | 1 | 0 | 10 | 22 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | |
| Edmond Tapsoba | Bayer Leverkusen | Defender | 14 | 0 | 0 | 2 | 0 | 0 | 12 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | |
| Daley Sinkgraven | Bayer Leverkusen | Midfielder | 13 | 0 | 1 | 1 | 0 | 0 | 11 | 14 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | |
| Paulinho | Bayer Leverkusen | Forward | 13 | 3 | 2 | 1 | 0 | 0 | 1 | 28 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Florian Wirtz | Bayer Leverkusen | Midfielder | 7 | 1 | 0 | 0 | 0 | 0 | 3 | 6 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | |
| Exequiel Palacios | Bayer Leverkusen | Midfielder | 3 | 0 | 0 | 0 | 0 | 0 | 2 | 8 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |
| Panagiotis Retsos | Bayer Leverkusen | Defender | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 17 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | |
| Joel Pohjanpalo | Bayer Leverkusen | Forward | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Ayman Azhil | Bayer Leverkusen | Midfielder | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Tin Jedvaj | Bayer Leverkusen | Defender | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Niklas Lomb | Bayer Leverkusen | Goalkeeper | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Adrian Stanilewicz | Bayer Leverkusen | Midfielder | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Ramazan Ozcan | Bayer Leverkusen | Goalkeeper | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A = Assists,
CS = Clean sheets Full
Sub = Started as a sub,
CO = Came on,
Off = Taken off,
S = Scored,
M = Missed,
Total = Total appearances,
OG = Own goals.