| MD | Players | Clubs | Nationality | DOB | A(D) |
|---|---|---|---|---|---|
| 15-Aug-2021 |  Maynor Figueroa | Houston Dynamo | Honduras | 02-May-1983 | 38(106) |
| 28-Oct-2021 | Chris Wondolowski | San Jose Earthquakes | United States | 28-Jul-1983 | 38(93) |
| 25-Apr-2021 | Lisandro Lopez | Atlanta United | Argentina | 02-Mar-1983 | 38(55) |
| 28-Oct-2021 | Drew Moor | Colorado Rapids | United States | 15-Jan-1984 | 37(287) |
| 24-Jun-2021 | Jordan Harvey | Los Angeles FC | United States | 28-Jan-1984 | 37(148) |
| 04-Nov-2021 | Brad Guzan | Atlanta United | United States | 09-Sep-1984 | 37(56) |
| 30-Oct-2021 | Federico Higuain | Inter Miami CF | Argentina | 25-Oct-1984 | 37(5) |
| 28-Oct-2021 | Jonathan Bornstein | Chicago Fire | United States | 07-Nov-1984 | 36(355) |
| 19-Aug-2021 | Oscar Boniek Garcia | Houston Dynamo | Honduras | 04-Sep-1984 | 36(349) |
| 28-Oct-2021 | Haris Medunjanin | Cincinnati | Bosnia and Herzegovina | 08-Mar-1985 | 36(234) |
| 31-Jul-2021 | Brad Knighton | New England Revolution | United States | 06-Feb-1985 | 36(175) |
| 27-Aug-2021 | Bradley Wright-Phillips | Columbus Crew | England | 12-Mar-1985 | 36(168) |
| 28-Oct-2021 | Geoff Cameron | Cincinnati | United States | 11-Jul-1985 | 36(109) |
| 29-Aug-2021 | Frederic Brillant | DC United | France | 26-Jun-1985 | 36(64) |
| 28-Oct-2021 | Sacha Kljestan | Los Angeles Galaxy | United States | 09-Sep-1985 | 36(49) |
| 31-Oct-2021 | Osvaldo Alonso | Minnesota United | Cuba | 11-Nov-1985 | 35(355) |
MD = Match date,
DOB = Date Of Birth,
A(D) = Age(Days).