| A(D) | Clubs | VS | MD | |
|---|---|---|---|---|
| 23(28) | Bayer Leverkusen | Celtic | 25-Nov-2021 | Match Details |
| 23(62) | AS Monaco | Real Sociedad | 30-Sep-2021 | Match Details |
| 24(333) | KRC Genk | Dinamo Zagreb | 30-Sep-2021 | Match Details |
| 24(30) | Lokomotiv Moscow | SS Lazio | 25-Nov-2021 | Match Details |
| 24(52) | Olympique Marseille | Galatasaray SK | 25-Nov-2021 | Match Details |
| 24(101) | Sporting Braga | FC Sheriff Tiraspol | 24-Feb-2022 | Match Details |
| 24(148) | Rapid Wien | Dinamo Zagreb | 21-Oct-2021 | Match Details |
| 24(169) | Barcelona | Galatasaray SK | 10-Mar-2022 | Match Details |
| 24(180) | FC Midtylland | Red Star Belgrade | 21-Oct-2021 | Match Details |
| 25(211) | Olympique Lyonnais | Rangers | 09-Dec-2021 | Match Details |
| 25(235) | Sturm Graz | Real Sociedad | 21-Oct-2021 | Match Details |
| 25(268) | Brondby | Olympique Lyonnais | 25-Nov-2021 | Match Details |
| 25(332) | Celtic | Real Betis | 16-Sep-2021 | Match Details |
| 25(67) | RB Leipzig | Rangers | 28-Apr-2022 | Match Details |
| 25(78) | Real Sociedad | PSV Eindhoven | 16-Sep-2021 | Match Details |
| 25(90) | Galatasaray SK | Olympique Marseille | 30-Sep-2021 | Match Details |
| 25(99) | Leicester City | Legia Warsaw | 25-Nov-2021 | Match Details |
| 25(101) | FC Sheriff Tiraspol | Sporting Braga | 24-Feb-2022 | Match Details |
| 25(169) | Eintracht Frankfurt | Real Betis | 09-Mar-2022 | Match Details |
| 25(170) | Spartak Moscow | Napoli | 30-Sep-2021 | Match Details |
| 26(300) | PSV Eindhoven | AS Monaco | 21-Oct-2021 | Match Details |
| 26(317) | Zenit St Petersburg | Real Betis | 24-Feb-2022 | Match Details |
| 26(342) | Sparta Prague | Brondby | 16-Sep-2021 | Match Details |
| 26(350) | Dinamo Zagreb | Rapid Wien | 04-Nov-2021 | Match Details |
| 26(356) | Royal Antwerp | Fenerbahce | 04-Nov-2021 | Match Details |
| 26(4) | FC Porto | Olympique Lyonnais | 17-Mar-2022 | Match Details |
| 26(91) | Legia Warsaw | Leicester City | 25-Nov-2021 | Match Details |
| 26(132) | Rangers | Olympique Lyonnais | 09-Dec-2021 | Match Details |
| 27(206) | Fenerbahce | Royal Antwerp | 04-Nov-2021 | Match Details |
| 27(259) | Ferencvaros | Bayer Leverkusen | 16-Sep-2021 | Match Details |
| 27(270) | Ludogorets Razgrad | Sporting Braga | 21-Oct-2021 | Match Details |
| 27(281) | Borussia Dortmund | Rangers | 17-Feb-2022 | Match Details |
| 27(28) | Olympiakos | Fenerbahce | 30-Sep-2021 | Match Details |
| 27(37) | West Ham United | KRC Genk | 21-Oct-2021 | Match Details |
| 27(69) | Napoli | Barcelona | 17-Feb-2022 | Match Details |
| 28(234) | Atalanta | Olympiakos | 17-Feb-2022 | Match Details |
| 28(341) | SS Lazio | Olympique Marseille | 21-Oct-2021 | Match Details |
| 28(8) | Red Star Belgrade | Ludogorets Razgrad | 25-Nov-2021 | Match Details |
| 29(218) | Sevilla | West Ham United | 10-Mar-2022 | Match Details |
| 29(345) | Real Betis | Zenit St Petersburg | 24-Feb-2022 | Match Details |
MD = Match date,
A(D) = Age(Days).