| A(D) | Clubs | VS | MD | |
|---|---|---|---|---|
| 30(97) | Malmo FF | Chelsea | 20-Oct-2021 | Match Details |
| 30(33) | Internazionale | Liverpool | 16-Feb-2022 | Match Details |
| 30(306) | Sevilla | Salzburg | 14-Sep-2021 | Match Details |
| 30(300) | Real Madrid | Chelsea | 12-Apr-2022 | Match Details |
| 29(179) | Benfica | Dynamo Kyiv | 08-Dec-2021 | Match Details |
| 29(136) | Liverpool | Atletico Madrid | 19-Oct-2021 | Match Details |
| 29(114) | Besiktas | Sporting Lisbon | 19-Oct-2021 | Match Details |
| 29(92) | Chelsea | Lille OSC | 16-Mar-2022 | Match Details |
| 29(26) | Villarreal | Liverpool | 03-May-2022 | Match Details |
| 29(20) | Atletico Madrid | AC Milan | 28-Sep-2021 | Match Details |
| 29(1) | Atalanta | Villarreal | 14-Sep-2021 | Match Details |
| 29(296) | Zenit St Petersburg | Malmo FF | 23-Nov-2021 | Match Details |
| 29(209) | Manchester City | RB Leipzig | 07-Dec-2021 | Match Details |
| 28(177) | Paris Saint-Germain | Club Brugge | 15-Sep-2021 | Match Details |
| 28(174) | Juventus | Malmo FF | 14-Sep-2021 | Match Details |
| 28(157) | FC Porto | Liverpool | 28-Sep-2021 | Match Details |
| 28(139) | Manchester United | Atletico Madrid | 23-Feb-2022 | Match Details |
| 28(98) | Bayern Munich | Salzburg | 16-Feb-2022 | Match Details |
| 28(34) | Sporting Lisbon | Manchester City | 09-Mar-2022 | Match Details |
| 28(249) | Barcelona | Bayern Munich | 14-Sep-2021 | Match Details |
| 28(193) | VfL Wolfsburg | Lille OSC | 14-Sep-2021 | Match Details |
| 27(141) | Lille OSC | Chelsea | 16-Mar-2022 | Match Details |
| 27(133) | Borussia Dortmund | Sporting Lisbon | 28-Sep-2021 | Match Details |
| 27(126) | Club Brugge | Manchester City | 03-Nov-2021 | Match Details |
| 27(355) | AFC Ajax | Benfica | 23-Feb-2022 | Match Details |
| 27(350) | Shakhtar Donetsk | Internazionale | 28-Sep-2021 | Match Details |
| 27(318) | AC Milan | Atletico Madrid | 24-Nov-2021 | Match Details |
| 27(304) | BSC Young Boys | Manchester United | 08-Dec-2021 | Match Details |
| 27(217) | Dynamo Kyiv | Barcelona | 02-Nov-2021 | Match Details |
| 27(203) | FC Sheriff Tiraspol | Real Madrid | 24-Nov-2021 | Match Details |
| 26(81) | RB Leipzig | Club Brugge | 28-Sep-2021 | Match Details |
| 24(248) | Salzburg | Bayern Munich | 16-Feb-2022 | Match Details |
MD = Match date,
A(D) = Age(Days).