| A(D) | Clubs | VS | MD | |
|---|---|---|---|---|
| 31(288) | Real Betis | Celtic | 16-Sep-2021 | Match Details |
| 30(183) | Red Star Belgrade | FC Midtylland | 21-Oct-2021 | Match Details |
| 30(95) | Rangers | Brondby | 04-Nov-2021 | Match Details |
| 30(87) | SS Lazio | FC Porto | 24-Feb-2022 | Match Details |
| 29(152) | Sevilla | Dinamo Zagreb | 17-Feb-2022 | Match Details |
| 29(359) | Atalanta | Bayer Leverkusen | 17-Mar-2022 | Match Details |
| 29(320) | West Ham United | KRC Genk | 04-Nov-2021 | Match Details |
| 29(265) | Zenit St Petersburg | Real Betis | 17-Feb-2022 | Match Details |
| 29(221) | Olympiakos | Atalanta | 17-Feb-2022 | Match Details |
| 28(167) | Napoli | Legia Warsaw | 21-Oct-2021 | Match Details |
| 28(160) | Ludogorets Razgrad | FC Midtylland | 16-Sep-2021 | Match Details |
| 28(64) | Leicester City | Napoli | 09-Dec-2021 | Match Details |
| 28(58) | Legia Warsaw | Spartak Moscow | 15-Sep-2021 | Match Details |
| 28(25) | Eintracht Frankfurt | Royal Antwerp | 30-Sep-2021 | Match Details |
| 28(338) | Ferencvaros | Celtic | 04-Nov-2021 | Match Details |
| 28(300) | Fenerbahce | Royal Antwerp | 21-Oct-2021 | Match Details |
| 28(244) | Royal Antwerp | Eintracht Frankfurt | 30-Sep-2021 | Match Details |
| 28(233) | Galatasaray SK | Olympique Marseille | 25-Nov-2021 | Match Details |
| 28(221) | Dinamo Zagreb | KRC Genk | 30-Sep-2021 | Match Details |
| 27(172) | Real Sociedad | RB Leipzig | 17-Feb-2022 | Match Details |
| 27(125) | Barcelona | Napoli | 24-Feb-2022 | Match Details |
| 27(114) | Borussia Dortmund | Rangers | 24-Feb-2022 | Match Details |
| 27(112) | Sparta Prague | Olympique Lyonnais | 04-Nov-2021 | Match Details |
| 27(46) | Olympique Lyonnais | Sparta Prague | 21-Oct-2021 | Match Details |
| 27(33) | FC Porto | SS Lazio | 24-Feb-2022 | Match Details |
| 27(20) | Lokomotiv Moscow | Galatasaray SK | 21-Oct-2021 | Match Details |
| 27(334) | PSV Eindhoven | Sturm Graz | 30-Sep-2021 | Match Details |
| 27(328) | Sporting Braga | FC Midtylland | 30-Sep-2021 | Match Details |
| 26(161) | RB Leipzig | Rangers | 05-May-2022 | Match Details |
| 26(154) | Celtic | Bayer Leverkusen | 25-Nov-2021 | Match Details |
| 26(104) | Brondby | Rangers | 21-Oct-2021 | Match Details |
| 26(74) | FC Midtylland | Sporting Braga | 25-Nov-2021 | Match Details |
| 26(57) | Spartak Moscow | Leicester City | 04-Nov-2021 | Match Details |
| 26(7) | Sturm Graz | PSV Eindhoven | 25-Nov-2021 | Match Details |
| 26(260) | Bayer Leverkusen | Real Betis | 21-Oct-2021 | Match Details |
| 26(244) | Olympique Marseille | SS Lazio | 04-Nov-2021 | Match Details |
| 26(201) | AS Monaco | Real Sociedad | 25-Nov-2021 | Match Details |
| 26(197) | FC Sheriff Tiraspol | Sporting Braga | 17-Feb-2022 | Match Details |
| 25(53) | Rapid Wien | West Ham United | 30-Sep-2021 | Match Details |
| 25(259) | KRC Genk | West Ham United | 21-Oct-2021 | Match Details |
MD = Match date,
A(D) = Age(Days).