| A(D) | Clubs | VS | MD | |
|---|---|---|---|---|
| 31(299) | Sporting Kansas City | Los Angeles FC | 04-Sep-2021 | Match Details |
| 31(276) | Columbus Crew | DC United | 08-May-2021 | Match Details |
| 31(273) | Inter Miami CF | Chicago Fire | 22-May-2021 | Match Details |
| 30(80) | Portland Timbers | Seattle Sounders | 30-Aug-2021 | Match Details |
| 30(304) | Toronto FC | Cincinnati | 27-Jun-2021 | Match Details |
| 30(279) | Minnesota United | Sporting Kansas City | 31-Oct-2021 | Match Details |
| 30(254) | Real Salt Lake | Austin FC | 15-Aug-2021 | Match Details |
| 29(188) | Chicago Fire | Philadelphia Union | 08-May-2021 | Match Details |
| 29(159) | Nashville SC | Inter Miami CF | 08-Aug-2021 | Match Details |
| 29(86) | New England Revolution | New York Red Bulls | 31-Jul-2021 | Match Details |
| 29(74) | Orlando City | Nashville SC | 31-Oct-2021 | Match Details |
| 29(69) | Cincinnati | Nashville SC | 28-Oct-2021 | Match Details |
| 29(22) | San Jose Earthquakes | Los Angeles Galaxy | 27-Jun-2021 | Match Details |
| 29(349) | DC United | Columbus Crew | 05-Aug-2021 | Match Details |
| 29(336) | Seattle Sounders | Columbus Crew | 21-Aug-2021 | Match Details |
| 29(334) | Houston Dynamo | Portland Timbers | 24-Jun-2021 | Match Details |
| 29(284) | Los Angeles Galaxy | Inter Miami CF | 18-Apr-2021 | Match Details |
| 28(181) | Austin FC | Vancouver Whitecaps | 05-Sep-2021 | Match Details |
| 28(164) | Colorado Rapids | New England Revolution | 28-Oct-2021 | Match Details |
| 28(109) | New York City | New York Red Bulls | 22-Aug-2021 | Match Details |
| 28(93) | FC Dallas | Colorado Rapids | 18-Apr-2021 | Match Details |
| 27(121) | Vancouver Whitecaps | Los Angeles FC | 03-Nov-2021 | Match Details |
| 27(87) | Philadelphia Union | DC United | 29-Aug-2021 | Match Details |
| 27(5) | Atlanta United | Chicago Fire | 25-Apr-2021 | Match Details |
| 27(333) | Montreal Impact | Atlanta United | 16-May-2021 | Match Details |
| 26(199) | Los Angeles FC | Austin FC | 17-Apr-2021 | Match Details |
| 25(18) | New York Red Bulls | Los Angeles Galaxy | 25-Apr-2021 | Match Details |
MD = Match date,
A(D) = Age(Days).