| 5 | David Beckham | Second Group Stage | UEFA Champions League 99/00 |
| 4 | Patrice Evra | Group Stage | UEFA Champions League 13/14 |
| 4 | Juan Sebastian Veron | First Group Stage | UEFA Champions League 02/03 |
| 4 | Paul Scholes | Quarter-finals | UEFA Champions League 99/00 |
| 4 | Paul Scholes | First Group Stage | UEFA Champions League 01/02 |
| 4 | Paul Scholes | First Group Stage | UEFA Champions League 00/01 |
| 3 | Axel Tuanzebe | Group Stage | UEFA Champions League 20/21 |
| 3 | Michael Carrick | Group Stage | UEFA Champions League 11/12 |
| 3 | Roy Keane | Semi-finals | UEFA Champions League 98/99 |
| 3 | Patrice Evra | Group Stage | UEFA Champions League 06/07 |
| 3 | Paul Scholes | Group Stage | UEFA Champions League 06/07 |
| 3 | Cristiano Ronaldo | Group Stage | UEFA Champions League 06/07 |
| 3 | Paul Scholes | Group Stage | UEFA Champions League 03/04 |
| 3 | Gary Neville | First Group Stage | UEFA Champions League 02/03 |
| 3 | Paul Scholes | Second Group Stage | UEFA Champions League 02/03 |
| 3 | Phil Neville | Second Group Stage | UEFA Champions League 02/03 |
| 3 | Nicky Butt | First Group Stage | UEFA Champions League 01/02 |
| 3 | David Beckham | First Group Stage | UEFA Champions League 00/01 |
| 3 | Nicky Butt | First Group Stage | UEFA Champions League 00/01 |
| 2 | Luke Shaw | Group Stage | UEFA Champions League 21/22 |
| 2 | Nemanja Matic | Group Stage | UEFA Champions League 21/22 |
| 2 | Alex Telles | Group Stage | UEFA Champions League 21/22 |
| 2 | Harry Maguire | Group Stage | UEFA Champions League 20/21 |
| 2 | Luke Shaw | Round of 16 | UEFA Champions League 18/19 |
| 2 | Ashley Young | Group Stage | UEFA Champions League 18/19 |
| 2 | Nemanja Matic | Group Stage | UEFA Champions League 18/19 |
| 2 | Ander Herrera | Group Stage | UEFA Champions League 18/19 |
| 2 | Jesse Lingard | Group Stage | UEFA Champions League 17/18 |
| 2 | Bruno Fernandes | Group Section | UEFA Champions League 23/24 |
| 2 | Sofyan Amrabat | Group Section | UEFA Champions League 23/24 |
| 2 | Rio Ferdinand | Round of 16 | UEFA Champions League 13/14 |
| 2 | Marouane Fellaini | Group Stage | UEFA Champions League 13/14 |
| 2 | Nemanja Vidic | Group Stage | UEFA Champions League 13/14 |
| 2 | Robin van Persie | Group Stage | UEFA Champions League 12/13 |
| 2 | Rafael Da Silva | Group Stage | UEFA Champions League 12/13 |
| 2 | Patrice Evra | Group Stage | UEFA Champions League 12/13 |
| 2 | Anderson | Group Stage | UEFA Champions League 10/11 |
| 2 | Paul Scholes | Round of 16 | UEFA Champions League 09/10 |
| 2 | Nemanja Vidic | Group Stage | UEFA Champions League 09/10 |
| 2 | Wayne Rooney | Round of 16 | UEFA Champions League 09/10 |
| 2 | Patrice Evra | Group Stage | UEFA Champions League 08/09 |
| 2 | Nemanja Vidic | Quarter-finals | UEFA Champions League 08/09 |
| 2 | Carlos Tevez | Group Stage | UEFA Champions League 08/09 |
| 2 | Cristiano Ronaldo | Group Stage | UEFA Champions League 08/09 |
| 2 | Wayne Rooney | Round of 16 | UEFA Champions League 08/09 |
| 2 | David May | Group Stage | UEFA Champions League 94/95 |
| 2 | Mark Hughes | Group Stage | UEFA Champions League 94/95 |
| 2 | Eric Cantona | Group Stage | UEFA Champions League 94/95 |
| 2 | Peter Schmeichel | Semi-finals | UEFA Champions League 98/99 |
| 2 | Denis Irwin | Quarter-finals | UEFA Champions League 98/99 |
| 2 | Roy Keane | Group Stage | UEFA Champions League 96/97 |
| 2 | Ole-Gunnar Solskjaer | Group Stage | UEFA Champions League 96/97 |
| 2 | Nani | Group Stage | UEFA Champions League 07/08 |
| 2 | Cristiano Ronaldo | Group Stage | UEFA Champions League 07/08 |
| 2 | Owen Hargreaves | Round of 16 | UEFA Champions League 07/08 |
| 2 | Patrice Evra | Group Stage | UEFA Champions League 07/08 |
| 2 | Gabriel Heinze | Group Stage | UEFA Champions League 06/07 |
| 2 | Alan Smith | Group Stage | UEFA Champions League 05/06 |
| 2 | Rio Ferdinand | Group Stage | UEFA Champions League 05/06 |
| 2 | Wayne Rooney | Group Stage | UEFA Champions League 05/06 |
