| 4 | Andre Almeida | Group Stage | UEFA Champions League 15/16 |
| 4 | Nemanja Matic | Group Stage | UEFA Champions League 12/13 |
| 4 | Pablo Aimar | Group Stage | UEFA Champions League 11/12 |
| 4 | Maxi Pereira | Group Stage | UEFA Champions League 11/12 |
| 3 | Enzo Fernandez | Group Stage | UEFA Champions League 22/23 |
| 3 | Nicolas Otamendi | Group Stage | UEFA Champions League 22/23 |
| 3 | Jardel | Group Stage | UEFA Champions League 18/19 |
| 3 | Andreas Samaris | Group Stage | UEFA Champions League 16/17 |
| 3 | Jardel | Group Stage | UEFA Champions League 15/16 |
| 3 | Jonas Goncalves | Group Stage | UEFA Champions League 15/16 |
| 3 | Andreas Samaris | Group Stage | UEFA Champions League 15/16 |
| 3 | Andreas Samaris | Group Stage | UEFA Champions League 14/15 |
| 3 | Bruno Cesar | Round of 16 | UEFA Champions League 11/12 |
| 3 | Javier Saviola | Group Stage | UEFA Champions League 10/11 |
| 3 | Nuno Gomes | Group Stage | UEFA Champions League 05/06 |
| 2 | Joao Mario | Group Stage | UEFA Champions League 22/23 |
| 2 | Florentino | Group Stage | UEFA Champions League 22/23 |
| 2 | David Neres | Group Stage | UEFA Champions League 22/23 |
| 2 | Goncalo Ramos | Group Stage | UEFA Champions League 22/23 |
| 2 | Julian Weigl | Group Stage | UEFA Champions League 21/22 |
| 2 | Nicolas Otamendi | Group Stage | UEFA Champions League 21/22 |
| 2 | Goncalo Ramos | Round of 16 | UEFA Champions League 21/22 |
| 2 | Rafa | Group Stage | UEFA Champions League 21/22 |
| 2 | Alex Grimaldo | Group Stage | UEFA Champions League 21/22 |
| 2 | Adel Taarabt | Group Stage | UEFA Champions League 21/22 |
| 2 | Roman Yaremchuk | Group Stage | UEFA Champions League 21/22 |
| 2 | Joao Mario | Group Stage | UEFA Champions League 21/22 |
| 2 | Gabriel | Group Stage | UEFA Champions League 19/20 |
| 2 | Ljubomir Fejsa | Group Stage | UEFA Champions League 18/19 |
| 2 | Ruben Dias | Group Stage | UEFA Champions League 18/19 |
| 2 | Luisao | Group Stage | UEFA Champions League 17/18 |
| 2 | Eduardo Salvio | Group Stage | UEFA Champions League 17/18 |
| 2 | Andreas Samaris | Group Stage | UEFA Champions League 17/18 |
| 2 | Ljubomir Fejsa | Group Stage | UEFA Champions League 16/17 |
| 2 | Pizzi | Group Stage | UEFA Champions League 16/17 |
| 2 | Luisao | Group Stage | UEFA Champions League 15/16 |
| 2 | Goncalo Guedes | Group Stage | UEFA Champions League 15/16 |
| 2 | Pizzi | Round of 16 | UEFA Champions League 15/16 |
| 2 | Morato | Group Section | UEFA Champions League 23/24 |
| 2 | Eduardo Salvio | Group Stage | UEFA Champions League 14/15 |
| 2 | Enzo Perez | Group Stage | UEFA Champions League 14/15 |
| 2 | Luisao | Group Stage | UEFA Champions League 14/15 |
| 2 | Enzo Perez | Group Stage | UEFA Champions League 13/14 |
| 2 | Nicolas Gaitan | Group Stage | UEFA Champions League 13/14 |
| 2 | Maxi Pereira | Group Stage | UEFA Champions League 13/14 |
| 2 | Bruno Cesar | Group Stage | UEFA Champions League 12/13 |
| 2 | Andre Almeida | Group Stage | UEFA Champions League 12/13 |
| 2 | Oscar Cardozo | Group Stage | UEFA Champions League 11/12 |
| 2 | Artur Moraes | Group Stage | UEFA Champions League 11/12 |
| 2 | Luisao | Round of 16 | UEFA Champions League 11/12 |
| 2 | Ezequiel Garay | Group Stage | UEFA Champions League 11/12 |
| 2 | Javi Garcia | Round of 16 | UEFA Champions League 11/12 |
| 2 | Javi Garcia | Group Stage | UEFA Champions League 10/11 |
| 2 | Nicolas Gaitan | Group Stage | UEFA Champions League 10/11 |
| 2 | Marques Isaias | Group Stage | UEFA Champions League 94/95 |
| 2 | Antonio Veloso | Quarter-finals | UEFA Champions League 94/95 |
| 2 | Carlos Mozer | Quarter-finals | UEFA Champions League 94/95 |
| 2 | Abel Xavier | Group Stage | UEFA Champions League 94/95 |
| 2 | Paulo Madeira | Group Stage | UEFA Champions League 98/99 |
| 2 | Michael Thomas | Group Stage | UEFA Champions League 98/99 |
