| 6 | Nicolas Tagliafico | Group Stage | UEFA Champions League 18/19 |
| 4 | Edson Alvarez | Group Stage | UEFA Champions League 21/22 |
| 4 | Danny Blind | Final | UEFA Champions League 94/95 |
| 4 | Danny Blind | Group Stage | UEFA Champions League 95/96 |
| 4 | Cristian Chivu | First Group Stage | UEFA Champions League 02/03 |
| 3 | Jurrien Timber | Group Stage | UEFA Champions League 21/22 |
| 3 | Andre Onana | Group Stage | UEFA Champions League 19/20 |
| 3 | Hakim Ziyech | Group Stage | UEFA Champions League 18/19 |
| 3 | Noussair Mazraoui | Group Stage | UEFA Champions League 18/19 |
| 3 | Joel Veltman | Group Stage | UEFA Champions League 14/15 |
| 3 | Luis Suarez | Group Stage | UEFA Champions League 10/11 |
| 3 | Nordin Wooter | Group Stage | UEFA Champions League 95/96 |
| 3 | Tomas Galasek | Group Stage | UEFA Champions League 05/06 |
| 3 | Rafael van der Vaart | Group Stage | UEFA Champions League 03/04 |
| 3 | Andy van der Meyde | First Group Stage | UEFA Champions League 02/03 |
| 3 | Tomas Galasek | First Group Stage | UEFA Champions League 02/03 |
| 2 | Kenneth Taylor | Group Stage | UEFA Champions League 22/23 |
| 2 | Jurrien Timber | Group Stage | UEFA Champions League 22/23 |
| 2 | Edson Alvarez | Group Stage | UEFA Champions League 22/23 |
| 2 | Perr Schuurs | Group Stage | UEFA Champions League 20/21 |
| 2 | Nicolas Tagliafico | Group Stage | UEFA Champions League 19/20 |
| 2 | Dusan Tadic | Group Stage | UEFA Champions League 19/20 |
| 2 | Lisandro Martinez | Group Stage | UEFA Champions League 19/20 |
| 2 | Quincy Promes | Group Stage | UEFA Champions League 19/20 |
| 2 | Joel Veltman | Group Stage | UEFA Champions League 19/20 |
| 2 | Daley Blind | Group Stage | UEFA Champions League 19/20 |
| 2 | Donny van de Beek | Group Stage | UEFA Champions League 18/19 |
| 2 | Matthijs de Ligt | Group Stage | UEFA Champions League 18/19 |
| 2 | Frenkie de Jong | Group Stage | UEFA Champions League 18/19 |
| 2 | Daley Blind | Group Stage | UEFA Champions League 18/19 |
| 2 | Lasse Schone | Group Stage | UEFA Champions League 18/19 |
| 2 | Andre Onana | Group Stage | UEFA Champions League 18/19 |
| 2 | Anwar El-Ghazi | Group Stage | UEFA Champions League 14/15 |
| 2 | Davy Klaassen | Group Stage | UEFA Champions League 14/15 |
| 2 | Niklas Moisander | Group Stage | UEFA Champions League 14/15 |
| 2 | Stefano Denswil | Group Stage | UEFA Champions League 13/14 |
| 2 | Daley Blind | Group Stage | UEFA Champions League 12/13 |
| 2 | Eyong Enoh | Group Stage | UEFA Champions League 11/12 |
| 2 | Demy de Zeeuw | Group Stage | UEFA Champions League 10/11 |
| 2 | Eyong Enoh | Group Stage | UEFA Champions League 10/11 |
| 2 | Finidi George | Group Stage | UEFA Champions League 94/95 |
| 2 | Frank de Boer | Semi-finals | UEFA Champions League 94/95 |
| 2 | Finidi George | Group Stage | UEFA Champions League 95/96 |
| 2 | Patrick Kluivert | Group Stage | UEFA Champions League 95/96 |
| 2 | Michael Reiziger | Semi-finals | UEFA Champions League 95/96 |
| 2 | Richard Witschge | Group Stage | UEFA Champions League 98/99 |
| 2 | Wamberto | Group Stage | UEFA Champions League 98/99 |
| 2 | Patrick Kluivert | Quarter-finals | UEFA Champions League 96/97 |
| 2 | Marcio Santos | Group Stage | UEFA Champions League 96/97 |
| 2 | Anthony Obodai | Group Stage | UEFA Champions League 04/05 |
| 2 | Wesley Sneijder | Group Stage | UEFA Champions League 04/05 |
| 2 | Steven Pienaar | Group Stage | UEFA Champions League 04/05 |
| 2 | Zlatan Ibrahimovic | Group Stage | UEFA Champions League 03/04 |
| 2 | Tomas Galasek | Group Stage | UEFA Champions League 03/04 |
| 2 | Nigel De Jong | Group Stage | UEFA Champions League 03/04 |
| 2 | Nigel De Jong | First Group Stage | UEFA Champions League 02/03 |
| 2 | Bogdan Lobont | Second Group Stage | UEFA Champions League 02/03 |
| 2 | Hossam Mido | First Group Stage | UEFA Champions League 02/03 |
| 2 | Steven Pienaar | First Group Stage | UEFA Champions League 02/03 |
| 2 | Zlatan Ibrahimovic | First Group Stage | UEFA Champions League 02/03 |
