| 8 | Diego Costa | Group Stage | UEFA Champions League 13/14 |
| 7 | Antoine Griezmann | Group Stage | UEFA Champions League 15/16 |
| 6 | Antoine Griezmann | Group Stage | UEFA Champions League 16/17 |
| 6 | Antoine Griezmann | Group Section | UEFA Champions League 23/24 |
| 5 | Alvaro Morata | Group Section | UEFA Champions League 23/24 |
| 5 | Mario Mandzukic | Group Stage | UEFA Champions League 14/15 |
| 5 | Milinko Pantic | Quarter-finals | UEFA Champions League 96/97 |
| 4 | Antoine Griezmann | Group Stage | UEFA Champions League 21/22 |
| 4 | Antoine Griezmann | Group Stage | UEFA Champions League 18/19 |
| 4 | Saul Niguez | Group Stage | UEFA Champions League 16/17 |
| 4 | Raul Garcia | Group Stage | UEFA Champions League 13/14 |
| 4 | Arda Turan | Group Stage | UEFA Champions League 13/14 |
| 4 | Diego Simeone | Group Stage | UEFA Champions League 96/97 |
| 3 | Joao Felix | Group Stage | UEFA Champions League 20/21 |
| 3 | Joao Felix | Group Stage | UEFA Champions League 19/20 |
| 3 | Alvaro Morata | Group Stage | UEFA Champions League 19/20 |
| 3 | Saul Niguez | Group Stage | UEFA Champions League 15/16 |
| 3 | Samuel Lino | Group Section | UEFA Champions League 23/24 |
| 3 | Maxi Rodriguez | Group Stage | UEFA Champions League 08/09 |
| 3 | Sergio Aguero | Group Stage | UEFA Champions League 08/09 |
| 3 | Juan Esnaider | Quarter-finals | UEFA Champions League 96/97 |
| 2 | Marcos Llorente | Round of 16 | UEFA Champions League 19/20 |
| 2 | Jose Maria Gimenez | Group Stage | UEFA Champions League 18/19 |
| 2 | Antoine Griezmann | Group Stage | UEFA Champions League 17/18 |
| 2 | Yannick Carrasco | Group Stage | UEFA Champions League 16/17 |
| 2 | Kevin Gameiro | Group Stage | UEFA Champions League 16/17 |
| 2 | Antoine Griezmann | Group Stage | UEFA Champions League 14/15 |
| 2 | Jorge Koke | Group Stage | UEFA Champions League 14/15 |
| 2 | Raul Garcia | Group Stage | UEFA Champions League 14/15 |
| 2 | Diego Godin | Group Stage | UEFA Champions League 13/14 |
| 2 | Adrian Lopez | Group Stage | UEFA Champions League 13/14 |
| 2 | Joao Miranda | Group Stage | UEFA Champions League 13/14 |
| 2 | Sergio Aguero | Group Stage | UEFA Champions League 09/10 |
| 2 | Simao Sabrosa | Group Stage | UEFA Champions League 08/09 |
| 2 | Kiko | Quarter-finals | UEFA Champions League 96/97 |
| 1 | Rodrigo de Paul | Group Stage | UEFA Champions League 22/23 |
| 1 | Antoine Griezmann | Group Stage | UEFA Champions League 22/23 |
| 1 | Mario Hermoso | Group Stage | UEFA Champions League 22/23 |
| 1 | Yannick Carrasco | Group Stage | UEFA Champions League 22/23 |
| 1 | Renan Lodi | Round of 16 | UEFA Champions League 21/22 |
| 1 | Rodrigo de Paul | Group Stage | UEFA Champions League 21/22 |
| 1 | Angel Correa | Group Stage | UEFA Champions League 21/22 |
| 1 | Luis Suarez | Group Stage | UEFA Champions League 21/22 |
| 1 | Joao Felix | Round of 16 | UEFA Champions League 21/22 |
| 1 | Jose Maria Gimenez | Group Stage | UEFA Champions League 20/21 |
| 1 | Yannick Carrasco | Group Stage | UEFA Champions League 20/21 |
| 1 | Marcos Llorente | Group Stage | UEFA Champions League 20/21 |
| 1 | Mario Hermoso | Group Stage | UEFA Champions League 20/21 |
| 1 | Thomas Partey | Group Stage | UEFA Champions League 19/20 |
| 1 | Saul Niguez | Round of 16 | UEFA Champions League 19/20 |
| 1 | Stefan Savic | Group Stage | UEFA Champions League 19/20 |
| 1 | Hector Herrera | Group Stage | UEFA Champions League 19/20 |
| 1 | Felipe | Group Stage | UEFA Champions League 19/20 |
| 1 | Diego Costa | Group Stage | UEFA Champions League 18/19 |
| 1 | Saul Niguez | Group Stage | UEFA Champions League 18/19 |
| 1 | Diego Godin | Round of 16 | UEFA Champions League 18/19 |
| 1 | Jorge Koke | Group Stage | UEFA Champions League 18/19 |
| 1 | Thomas Partey | Group Stage | UEFA Champions League 17/18 |
| 1 | Kevin Gameiro | Group Stage | UEFA Champions League 17/18 |
| 1 | Saul Niguez | Group Stage | UEFA Champions League 17/18 |
