| 12 | Erling Haaland | Group Stage | UEFA Champions League 22/23 |
| 7 | Riyad Mahrez | Group Stage | UEFA Champions League 21/22 |
| 6 | Gabriel Jesus | Group Stage | UEFA Champions League 19/20 |
| 6 | Raheem Sterling | Group Stage | UEFA Champions League 19/20 |
| 6 | Sergio Aguero | Group Stage | UEFA Champions League 18/19 |
| 6 | Erling Haaland | Group Section | UEFA Champions League 23/24 |
| 6 | Sergio Aguero | Group Stage | UEFA Champions League 14/15 |
| 6 | Sergio Aguero | Group Stage | UEFA Champions League 13/14 |
| 5 | Raheem Sterling | Group Stage | UEFA Champions League 18/19 |
| 5 | Sergio Aguero | Group Stage | UEFA Champions League 16/17 |
| 5 | Julian Alvarez | Group Section | UEFA Champions League 23/24 |
| 5 | Phil Foden | Group Section | UEFA Champions League 23/24 |
| 5 | Alvaro Negredo | Group Stage | UEFA Champions League 13/14 |
| 4 | Gabriel Jesus | Group Stage | UEFA Champions League 21/22 |
| 4 | Riyad Mahrez | Quarter-finals | UEFA Champions League 20/21 |
| 4 | Ferran Torres | Group Stage | UEFA Champions League 20/21 |
| 4 | Gabriel Jesus | Group Stage | UEFA Champions League 18/19 |
| 4 | Leroy Sane | Group Stage | UEFA Champions League 18/19 |
| 4 | Gabriel Jesus | Group Stage | UEFA Champions League 17/18 |
| 4 | Sergio Aguero | Group Stage | UEFA Champions League 17/18 |
| 4 | Raheem Sterling | Group Stage | UEFA Champions League 17/18 |
| 3 | Riyad Mahrez | Group Stage | UEFA Champions League 22/23 |
| 3 | Julian Alvarez | Group Stage | UEFA Champions League 22/23 |
| 3 | Bernardo Silva | Quarter-finals | UEFA Champions League 22/23 |
| 3 | Raheem Sterling | Group Stage | UEFA Champions League 21/22 |
| 3 | Phil Foden | Group Stage | UEFA Champions League 21/22 |
| 3 | Bernardo Silva | Round of 16 | UEFA Champions League 21/22 |
| 3 | Ilkay Gundogan | Group Stage | UEFA Champions League 20/21 |
| 3 | Phil Foden | Group Stage | UEFA Champions League 20/21 |
| 3 | Kevin De Bruyne | Round of 16 | UEFA Champions League 20/21 |
| 3 | Bernardo Silva | Group Stage | UEFA Champions League 18/19 |
| 3 | John Stones | Group Stage | UEFA Champions League 17/18 |
| 3 | Raheem Sterling | Group Stage | UEFA Champions League 15/16 |
| 3 | Kevin De Bruyne | Group Stage | UEFA Champions League 15/16 |
| 3 | Yaya Toure | Group Stage | UEFA Champions League 11/12 |
| 2 | Kevin De Bruyne | Round of 16 | UEFA Champions League 22/23 |
| 2 | Rodri Hernandez | Quarter-finals | UEFA Champions League 22/23 |
| 2 | Joao Cancelo | Group Stage | UEFA Champions League 21/22 |
| 2 | Kevin De Bruyne | Quarter-finals | UEFA Champions League 21/22 |
| 2 | Gabriel Jesus | Group Stage | UEFA Champions League 20/21 |
| 2 | Sergio Aguero | Group Stage | UEFA Champions League 20/21 |
| 2 | Ilkay Gundogan | Group Stage | UEFA Champions League 19/20 |
| 2 | Phil Foden | Group Stage | UEFA Champions League 19/20 |
| 2 | Sergio Aguero | Group Stage | UEFA Champions League 19/20 |
| 2 | Kevin De Bruyne | Round of 16 | UEFA Champions League 19/20 |
| 2 | David Silva | Group Stage | UEFA Champions League 18/19 |
| 2 | Ilkay Gundogan | Round of 16 | UEFA Champions League 17/18 |
| 2 | Kelechi Iheanacho | Group Stage | UEFA Champions League 16/17 |
| 2 | Ilkay Gundogan | Group Stage | UEFA Champions League 16/17 |
| 2 | Leroy Sane | Round of 16 | UEFA Champions League 16/17 |
| 2 | Raheem Sterling | Group Stage | UEFA Champions League 16/17 |
| 2 | Fernandinho | Group Stage | UEFA Champions League 15/16 |
| 2 | Sergio Aguero | Group Stage | UEFA Champions League 15/16 |
| 2 | Wilfried Bony | Group Stage | UEFA Champions League 15/16 |
| 2 | David Silva | Group Stage | UEFA Champions League 15/16 |
| 2 | Manuel Akanji | Group Section | UEFA Champions League 23/24 |
| 2 | Kevin De Bruyne | Round of 16 | UEFA Champions League 23/24 |
| 2 | Bernardo Silva | Round of 16 | UEFA Champions League 23/24 |
| 2 | Edin Dzeko | Group Stage | UEFA Champions League 13/14 |
| 2 | Sergio Aguero | Group Stage | UEFA Champions League 12/13 |
