| 4 | Konstantinos Mitroglou | Group Stage | UEFA Champions League 12/13 |
| 4 | Sinica Gogic | Quarter-finals | UEFA Champions League 98/99 |
| 4 | Predrag Djordjevic | First Group Stage | UEFA Champions League 02/03 |
| 4 | Giovanni | First Group Stage | UEFA Champions League 99/00 |
| 3 | Youssef El-Arabi | Group Stage | UEFA Champions League 19/20 |
| 3 | Felipe Pardo | Group Stage | UEFA Champions League 15/16 |
| 3 | Alejandro Dominguez | Group Stage | UEFA Champions League 13/14 |
| 3 | Konstantinos Mitroglou | Group Stage | UEFA Champions League 13/14 |
| 3 | Ieroklis Stoltidis | Group Stage | UEFA Champions League 07/08 |
| 3 | Luciano Galletti | Group Stage | UEFA Champions League 07/08 |
| 3 | Darko Kovacevic | Group Stage | UEFA Champions League 07/08 |
| 3 | Nery Castillo | Group Stage | UEFA Champions League 06/07 |
| 3 | Giovanni | First Group Stage | UEFA Champions League 00/01 |
| 2 | Ruben Semedo | Group Stage | UEFA Champions League 19/20 |
| 2 | Felipe Pardo | Group Stage | UEFA Champions League 17/18 |
| 2 | Ibrahim Afellay | Group Stage | UEFA Champions League 14/15 |
| 2 | Konstantinos Mitroglou | Group Stage | UEFA Champions League 14/15 |
| 2 | Kostas Manolas | Group Stage | UEFA Champions League 13/14 |
| 2 | Javier Saviola | Group Stage | UEFA Champions League 13/14 |
| 2 | Francois Modesto | Group Stage | UEFA Champions League 11/12 |
| 2 | Rafik Djebbour | Group Stage | UEFA Champions League 11/12 |
| 2 | David Fuster | Group Stage | UEFA Champions League 11/12 |
| 2 | Konstantinos Mitroglou | Group Stage | UEFA Champions League 09/10 |
| 2 | Stelios Giannakopoulos | Group Stage | UEFA Champions League 98/99 |
| 2 | Alekos Alexandris | Group Stage | UEFA Champions League 98/99 |
| 2 | Mihalis Konstantinou | Group Stage | UEFA Champions League 06/07 |
| 2 | Rivaldo | Group Stage | UEFA Champions League 05/06 |
| 2 | Pantelis Kafes | Group Stage | UEFA Champions League 05/06 |
| 2 | Nery Castillo | Group Stage | UEFA Champions League 03/04 |
| 2 | Ieroklis Stoltidis | Group Stage | UEFA Champions League 03/04 |
| 2 | Zlatko Zahovic | First Group Stage | UEFA Champions League 99/00 |
| 2 | Stelios Giannakopoulos | First Group Stage | UEFA Champions League 01/02 |
| 2 | Alekos Alexandris | First Group Stage | UEFA Champions League 01/02 |
| 2 | Predrag Djordjevic | First Group Stage | UEFA Champions League 00/01 |
| 1 | Mady Camara | Group Stage | UEFA Champions League 20/21 |
| 1 | Ahmed Hassan | Group Stage | UEFA Champions League 20/21 |
| 1 | Guilherme | Group Stage | UEFA Champions League 19/20 |
| 1 | Mathieu Valbuena | Group Stage | UEFA Champions League 19/20 |
| 1 | Daniel Podence | Group Stage | UEFA Champions League 19/20 |
| 1 | Dimitris Nikolaou | Group Stage | UEFA Champions League 17/18 |
| 1 | Vadis Odjidja-Ofoe | Group Stage | UEFA Champions League 17/18 |
| 1 | Alfred Finnbogason | Group Stage | UEFA Champions League 15/16 |
| 1 | Brown Ideye | Group Stage | UEFA Champions League 15/16 |
| 1 | Delvin N'Dinga | Group Stage | UEFA Champions League 14/15 |
| 1 | Alberto Botia | Group Stage | UEFA Champions League 14/15 |
| 1 | Arthur Masuaku | Group Stage | UEFA Champions League 14/15 |
| 1 | Alejandro Dominguez | Group Stage | UEFA Champions League 14/15 |
| 1 | Pajtim Kasami | Group Stage | UEFA Champions League 14/15 |
| 1 | David Fuster | Group Stage | UEFA Champions League 14/15 |
| 1 | Vladimir Weiss | Group Stage | UEFA Champions League 13/14 |
| 1 | Joel Campbell | Round of 16 | UEFA Champions League 13/14 |
| 1 | Djamel Abdoun | Group Stage | UEFA Champions League 12/13 |
| 1 | Leandro Greco | Group Stage | UEFA Champions League 12/13 |
| 1 | Giannis Maniatis | Group Stage | UEFA Champions League 12/13 |
| 1 | Vasilis Torosidis | Group Stage | UEFA Champions League 12/13 |
| 1 | Paulo Machado | Group Stage | UEFA Champions League 12/13 |
| 1 | Jose Holebas | Group Stage | UEFA Champions League 11/12 |
| 1 | Ioannis Fetfatazidis | Group Stage | UEFA Champions League 11/12 |
| 1 | Ieroklis Stoltidis | Group Stage | UEFA Champions League 09/10 |
| 1 | Leonardo | Group Stage | UEFA Champions League 09/10 |
