| 10 | Mario Jardel | Quarter-finals | UEFA Champions League 99/00 |
| 7 | Jackson Martinez | Group Stage | UEFA Champions League 14/15 |
| 7 | Zlatko Zahovic | Group Stage | UEFA Champions League 98/99 |
| 6 | Moussa Marega | Group Stage | UEFA Champions League 18/19 |
| 6 | Lisandro Lopez | Group Stage | UEFA Champions League 08/09 |
| 5 | Mehdi Taremi | Group Stage | UEFA Champions League 22/23 |
| 5 | Vincent Aboubakar | Group Stage | UEFA Champions League 17/18 |
| 5 | Galeno | Group Section | UEFA Champions League 23/24 |
| 5 | Yacine Brahimi | Group Stage | UEFA Champions League 14/15 |
| 4 | Evanilson | Group Section | UEFA Champions League 23/24 |
| 4 | Hulk | Group Stage | UEFA Champions League 11/12 |
| 4 | Radamel Falcao | Group Stage | UEFA Champions League 09/10 |
| 4 | Mario Jardel | Group Stage | UEFA Champions League 96/97 |
| 4 | Artur | Group Stage | UEFA Champions League 96/97 |
| 4 | Benni McCarthy | Group Stage | UEFA Champions League 03/04 |
| 3 | Sergio Oliveira | Group Stage | UEFA Champions League 20/21 |
| 3 | Jesus Manuel Corona | Group Stage | UEFA Champions League 18/19 |
| 3 | Andre Silva | Group Stage | UEFA Champions League 16/17 |
| 3 | Vincent Aboubakar | Group Stage | UEFA Champions League 15/16 |
| 3 | Ricardo Quaresma | Group Stage | UEFA Champions League 14/15 |
| 3 | Vincent Aboubakar | Group Stage | UEFA Champions League 14/15 |
| 3 | Hector Herrera | Group Stage | UEFA Champions League 14/15 |
| 3 | Jackson Martinez | Group Stage | UEFA Champions League 12/13 |
| 3 | Hulk | Group Stage | UEFA Champions League 09/10 |
| 3 | Jose Carlos | Group Stage | UEFA Champions League 92/93 |
| 3 | Mario Jardel | Group Stage | UEFA Champions League 97/98 |
| 3 | Lisandro Lopez | Group Stage | UEFA Champions League 07/08 |
| 3 | Lucho Gonzalez | Group Stage | UEFA Champions League 07/08 |
| 3 | Lucho Gonzalez | Group Stage | UEFA Champions League 06/07 |
| 3 | Lisandro Lopez | Group Stage | UEFA Champions League 06/07 |
| 3 | Benni McCarthy | Group Stage | UEFA Champions League 04/05 |
| 3 | Maniche | Group Stage | UEFA Champions League 03/04 |
| 3 | Derlei | Group Stage | UEFA Champions League 03/04 |
| 3 | Costinha | Group Stage | UEFA Champions League 03/04 |
| 3 | Dmitri Alenichev | Group Stage | UEFA Champions League 03/04 |
| 3 | Deco | First Group Stage | UEFA Champions League 99/00 |
| 3 | Pena | First Group Stage | UEFA Champions League 01/02 |
| 3 | Clayton | First Group Stage | UEFA Champions League 01/02 |
| 2 | Galeno | Group Stage | UEFA Champions League 22/23 |
| 2 | Stephen Eustaquio | Group Stage | UEFA Champions League 22/23 |
| 2 | Luis Diaz | Group Stage | UEFA Champions League 21/22 |
| 2 | Moussa Marega | Group Stage | UEFA Champions League 20/21 |
| 2 | Mehdi Taremi | Round of 16 | UEFA Champions League 20/21 |
| 2 | Luis Diaz | Group Stage | UEFA Champions League 20/21 |
| 2 | Eder Militao | Group Stage | UEFA Champions League 18/19 |
| 2 | Hector Herrera | Group Stage | UEFA Champions League 18/19 |
| 2 | Otavio | Group Stage | UEFA Champions League 18/19 |
| 2 | Andre Andre | Group Stage | UEFA Champions League 15/16 |
| 2 | Mehdi Taremi | Group Section | UEFA Champions League 23/24 |
| 2 | Pepe | Group Section | UEFA Champions League 23/24 |
| 2 | Lucho Gonzalez | Group Stage | UEFA Champions League 13/14 |
| 2 | Jackson Martinez | Group Stage | UEFA Champions League 13/14 |
| 2 | Lucho Gonzalez | Group Stage | UEFA Champions League 12/13 |
| 2 | Joao Moutinho | Group Stage | UEFA Champions League 12/13 |
| 2 | Silvestre Varela | Group Stage | UEFA Champions League 12/13 |
| 2 | Lucho Gonzalez | Group Stage | UEFA Champions League 08/09 |
| 2 | Carlos Secretario | Group Stage | UEFA Champions League 93/94 |
| 2 | Domingos | Group Stage | UEFA Champions League 93/94 |
| 2 | Emerson | Group Stage | UEFA Champions League 95/96 |
| 2 | Rui Barros | Group Stage | UEFA Champions League 95/96 |
