| 5 | Ruud van Nistelrooy | Group Stage | UEFA Champions League 98/99 |
| 4 | Danny Koevermans | Group Stage | UEFA Champions League 08/09 |
| 3 | Luuk De Jong | Group Stage | UEFA Champions League 18/19 |
| 3 | Luuk De Jong | Group Section | UEFA Champions League 23/24 |
| 3 | Romario | Group Stage | UEFA Champions League 92/93 |
| 3 | Gilles De Bilde | Group Stage | UEFA Champions League 97/98 |
| 3 | DaMarcus Beasley | Group Stage | UEFA Champions League 04/05 |
| 3 | Phillip Cocu | Semi-finals | UEFA Champions League 04/05 |
| 3 | Ruud van Nistelrooy | First Group Stage | UEFA Champions League 99/00 |
| 2 | Hirving Lozano | Group Stage | UEFA Champions League 18/19 |
| 2 | Maxime Lestienne | Group Stage | UEFA Champions League 15/16 |
| 2 | Luuk De Jong | Group Stage | UEFA Champions League 15/16 |
| 2 | Dmitri Khokhlov | Group Stage | UEFA Champions League 98/99 |
| 2 | Wim Jonk | Group Stage | UEFA Champions League 97/98 |
| 2 | Alex Costa | Group Stage | UEFA Champions League 06/07 |
| 2 | Jefferson Farfan | Group Stage | UEFA Champions League 05/06 |
| 2 | Jan Vennegoor of Hesselink | Group Stage | UEFA Champions League 04/05 |
| 2 | Alex Costa | Round of 16 | UEFA Champions League 04/05 |
| 2 | Wilfred Bouma | Group Stage | UEFA Champions League 03/04 |
| 2 | John de Jong | Group Stage | UEFA Champions League 03/04 |
| 2 | Arjen Robben | Group Stage | UEFA Champions League 03/04 |
| 2 | Arnold Bruggink | First Group Stage | UEFA Champions League 02/03 |
| 2 | Mateja Kezman | First Group Stage | UEFA Champions League 01/02 |
| 2 | Mark van Bommel | First Group Stage | UEFA Champions League 00/01 |
| 2 | Adil Ramzi | First Group Stage | UEFA Champions League 00/01 |
| 1 | Pablo Rosario | Group Stage | UEFA Champions League 18/19 |
| 1 | Luuk De Jong | Group Stage | UEFA Champions League 16/17 |
| 1 | Davy Propper | Group Stage | UEFA Champions League 16/17 |
| 1 | Luciano Narsingh | Group Stage | UEFA Champions League 16/17 |
| 1 | Santiago Arias | Group Stage | UEFA Champions League 16/17 |
| 1 | Hector Moreno | Group Stage | UEFA Champions League 15/16 |
| 1 | Jurgen Locadia | Group Stage | UEFA Champions League 15/16 |
| 1 | Luciano Narsingh | Group Stage | UEFA Champions League 15/16 |
| 1 | Davy Propper | Group Stage | UEFA Champions League 15/16 |
| 1 | Jordan Teze | Group Section | UEFA Champions League 23/24 |
| 1 | Yorbe Vertessen | Group Section | UEFA Champions League 23/24 |
| 1 | Johan Bakayoko | Group Section | UEFA Champions League 23/24 |
| 1 | Ricardo Pepi | Group Section | UEFA Champions League 23/24 |
| 1 | Ismael Saibari | Group Section | UEFA Champions League 23/24 |
| 1 | Danko Lazovic | Group Stage | UEFA Champions League 08/09 |
| 1 | Arthur Numan | Group Stage | UEFA Champions League 92/93 |
| 1 | Andre Ooijer | Group Stage | UEFA Champions League 98/99 |
| 1 | Arnold Bruggink | Group Stage | UEFA Champions League 98/99 |
| 1 | Dennis Rommedahl | Group Stage | UEFA Champions League 98/99 |
| 1 | Luc Nilis | Group Stage | UEFA Champions League 97/98 |
| 1 | Phillip Cocu | Group Stage | UEFA Champions League 97/98 |
| 1 | Peter Moller | Group Stage | UEFA Champions League 97/98 |
| 1 | Jefferson Farfan | Group Stage | UEFA Champions League 07/08 |
| 1 | Kenneth Perez | Group Stage | UEFA Champions League 07/08 |
| 1 | Danko Lazovic | Group Stage | UEFA Champions League 07/08 |
| 1 | Mika Vayrynen | Group Stage | UEFA Champions League 06/07 |
| 1 | Jan Kromkamp | Group Stage | UEFA Champions League 06/07 |
| 1 | Edison Mendez | Round of 16 | UEFA Champions League 06/07 |
| 1 | Timmy Simons | Group Stage | UEFA Champions League 06/07 |
| 1 | Arouna Kone | Group Stage | UEFA Champions League 06/07 |
| 1 | Jan Vennegoor of Hesselink | Group Stage | UEFA Champions League 05/06 |
| 1 | Phillip Cocu | Group Stage | UEFA Champions League 05/06 |
| 1 | Andre Ooijer | Group Stage | UEFA Champions League 04/05 |
| 1 | Ji Sung Park | Semi-finals | UEFA Champions League 04/05 |
| 1 | John de Jong | Group Stage | UEFA Champions League 04/05 |
